Antiviral Efficacy and Pharmacokinetics of Oral Adefovir Dipivoxil in Chronically Woodchuck Hepatitis Virus-Infected Woodchucks
نویسندگان
چکیده
منابع مشابه
Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks.
The antiviral efficacy of orally administered adefovir dipivoxil was evaluated in an 18-week study (12 weeks of treatment and 6 weeks of recovery) conducted with woodchucks chronically infected with woodchuck hepatitis virus (WHV). Adefovir dipivoxil is a prodrug of adefovir designed to enhance its oral bioavailability. Following administration of 15 mg of adefovir dipivoxil per kg of body weig...
متن کاملNitrite and nitrosamine synthesis by hepatocytes isolated from normal woodchucks (Marmota monax) and woodchucks chronically infected with woodchuck hepatitis virus.
Hepatocytes isolated from woodchucks (Marmota monax) were shown to produce nitrite in vitro from L-arginine after stimulation with lipopolysaccharide (LPS). Hepatocytes isolated from woodchucks that were chronic carriers of woodchuck hepatitis virus formed twice as much nitrite as hepatocytes from noninfected animals. Nitrite synthesis by hepatocytes was directly related to L-arginine and LPS c...
متن کاملEffect of Hepatitis B Virus Genotypes on the Efficacy of Adefovir Dipivoxil Antiviral Therapy
BACKGROUND Hepatitis B is a common infectious disease in China. Many studies have shown that the genotype of hepatitis B virus (HBV) is probably associated with the efficacy of some antiviral drugs such as interferon α (IFN-α) and Lamivudine (LAM). However, the association between HBV genotype and adefovir dipivoxil (ADV) is controversial. ADV is the most popular antiviral drug in China due to ...
متن کاملeffect of hepatitis b virus genotypes on the efficacy of adefovir dipivoxil antiviral therapy
results genotype b (73.6%) and genotype c (26.4%) were detected in these patients. after treatment for 12 months, the rate of hbv dna seroclearance, alt normalization, and hbeag seroconversion were significantly higher in adv group than in placebo group (p < 0.05). however, there were no significant differences in these three rates between patients infected with genotype b and c (p > 0.05). obj...
متن کاملNitrite and Nitrosamine Synthesis by Hepatocytes Isolated from Normal Woodchucks (Marmota monax) and Woodchucks Chronically Infected with Woodchuck Hepatitis Virus1
Hepatocytes isolated from woodchucks (Marmota monax) were shown to produce nitrite in vitro from i.-arginine after stimulation with lipopolysaccharide (LPS). Hepatocytes isolated from woodchucks that were chronic carriers of woodchuck hepatitis virus formed twice as much nitrite as hepatocytes from noninfected animals. Nitrite synthesis by hepatocytes was directly related to i-arginine and LPS ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2001
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.45.10.2740-2745.2001